Transdisciplinary ways of collaborating are considered essential to support the generation of new approaches to tackling societal and environmental “wicked” problems. But how can collaborations take place in ways that reach this envisioned state? In this work, we look for cues of transdisciplinarity in the experience of those with a successful track record of working across disciplines. We investigate the experience of 69 practitioners and researchers working in “creative biology”, an umbrella term that we use to address work that incorporates biology-related methods and research outside purely scientific realms. Our study provides insights into how language is often used to support strategic shifts of positionality and nudge others to step out of their disciplinary realms, contributing examples that can help expand the discussion of transdisciplinarity in Design.